Albumin-to-Globulin Ratio Calculator

About this calculator

The albumin-to-globulin (A/G) ratio compares the two major protein groups in your blood: albumin, made in the liver, and globulins, a mixed group including antibodies. Since routine blood panels report total protein and albumin directly, globulin is worked out by subtraction (total protein − albumin), and the ratio is then albumin ÷ globulin — a normal result typically falls around 1.1 to 2.5, meaning albumin normally outweighs globulin somewhat.

A low A/G ratio can point either to too little albumin (seen in liver disease, kidney disease that leaks protein, or malnutrition) or too much globulin (seen in chronic inflammation, autoimmune disease, or blood cancers like multiple myeloma that flood the blood with abnormal antibody proteins), while a high ratio is less common and can suggest conditions that suppress globulin production. Because the ratio alone doesn’t say which side of the equation moved, physicians read it alongside the individual albumin and total protein values, and often alongside protein electrophoresis, to narrow down the cause.

Enter your serum albumin and total protein, and this calculator returns the globulin level and the A/G ratio, with a note on how the result is typically interpreted.